Table 3.
Degree of diagnostic accuracy in HCC vs. non-hepatocytic malignancy (NHM) nodules and non-malignant (NM) nodules in liver biopsy (test cohort).
| HCC vs. NM | HCC (n = 100) | NM (n = 62) | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|
| Both positive | 26 | 0 | 26.0% | 100% | 100% | 45.6% | 54.3% |
| At least one positive | 84 | 4 | 84.0% | 93.5% | 95.5% | 78.4% | 87.7% |
| AFP RNAscope | 45 | 0 | 45.0% | 100% | 100% | 53.0% | 66.0% |
| GPC3 IHC | 66 | 4 | 66.0% | 93.5% | 94.3% | 63.0% | 76.5% |
| HCC vs. NHM | HCC (n = 100) | NHM (n = 93) | Sensitivity | Specificity | PPV | NPV | Accuracy |
|---|---|---|---|---|---|---|---|
| All positive | 18 | 0 | 18.0% | 100% | 100% | 53.1% | 57.5% |
| At least one positive | 96 | 12 | 96.0% | 87.1% | 88.9% | 95.3% | 91.7% |
| AFP RNAscope | 45 | 0 | 45.0% | 100% | 100% | 62.8% | 71.5% |
| GPC3 IHC | 66 | 12 | 66.0% | 87.1% | 84.6% | 70.4% | 76.2% |
| HepPar-1 | 81 | 2 | 81.0% | 97.8% | 97.6% | 82.7% | 89.1% |
| Arg-1 | 61 | 1 | 61.0% | 98.4% | 98.4% | 70.2% | 79.3% |
HCC hepatocellular carcinoma, PPV positive predictive value, NNP negative predictive value.