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. 2021 Jun 7;12(6):585. doi: 10.1038/s41419-021-03856-9

Fig. 3. TRPM2 promotes the proliferation, migration and invasion of BxPC-3 pancreatic cancer cells.

Fig. 3

a qRT-PCR results of TRPM2 expression level in different experimental groups of BxPC-3 cells: TRPM2 overexpressed (TRPM2), TRPM2 siRNA, scramble siRNA, empty vector (Empty_Vec), and normal control (NC) groups. ****P < 0.0001. b CCK8 assay results of different groups at 0-, 24-, and 48-h time intervals. *P < 0.05, **P < 0.01, siRNA, small interfering RNA; CCK8, cell counting kit-8; OD, optical density. c Transwell assay results showed that the TRPM2 overexpression group has a stronger invasive ability and TRPM2 siRNA group has a weaker invasive ability. Images under microscopy (magnification ×100). *P < 0.05. d Scratch wound healing assay results. Images of all groups at 0- and 24-h time intervals post injury (magnification ×100). *P < 0.05, **P < 0.01 (3 repeats for each group).