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. 2021 Jun 7;12(6):585. doi: 10.1038/s41419-021-03856-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Tumors of nude mice (3 repeats in each group). b Weekly volume change of nude mice implanted tumors (3 repeats in each group). c Weight change of nude mice implanted tumors after six weeks. (OE: TRPM2 overexpression, NC: normal control, TRPM2 siRNA: TRPM2 interference expression group, *P < 0.05, ***P < 0.001, ****P < 0.0001, 3 repeats in each group). d Heatmap of top 40 differentially expressed genes (DEG) between TT and TP groups of patients’ PA samples (12 samples each for TT or TP samples). e PCA clustering showed significant differences among NC, OE, and siRNA groups (3 samples in each group). f Heatmap of DEGs among NC, OE, and siRNA groups (3 samples in each group).