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. 2021 Jun 7;11:11940. doi: 10.1038/s41598-021-91576-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Leukemia cutis. A 42-year-old woman with AML who underwent biopsy of a skin eruption. (A) The patient presented with hyperleukocytosis and abdominal purple striae-like infiltrated plaques in a reticulated pattern. (B,C) A punch biopsy performed from the right abdomen revealed a mild perivascular infiltrate in the dermis, composed of medium-sized immature atypical cells, otherwise unremarkable. The epidermis shows no significant changes; note the subepidermal Grenz zone (H&E, X100). (C) Same as (B) at higher magnification (H&E X400). (D,E) The atypical cells stain positive for CD45 (X200) (D) ,CD4 (X200)) E) ,HLA-DR, CD11c, CD68 and lysozyme. Cells are negative for CD3, CD20, CD79a, CD34, CD138, TdT, CD30, CD123 and cytokeratin. Ki67 shows a proliferative index of 25% in the infiltrates. The overall histological findings together with the immunohistochemical stains are compatible with AML involving the skin (leukemia cutis).