Figure 1.

Predicted relative effects of blocking metabolic enzymes, on the healthy lung cells and the infected cells, respectively (A). Schema summarizing the role of the identified drug targets on the assembly of virions (B). Illustration of how the inhibition of an enzyme modifies the space of feasible metabolic flux distributions. The method used in this work searches to decrease the metabolic capabilities for the formation of virions, while keeping limited effects on the formation of cellular biomass (C).