Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 25;9:659428. doi: 10.3389/fcell.2021.659428

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Nadanaka, Bai and Kitagawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

C4ST-1 controls BT-549 cell proliferation by regulating the cleavage of SDC1 by MMPs. SDC1 expressed at the cell surface is cleaved by MMPs, and the N-terminal and the C-terminal fragments of SDC1 are generated. Both fragments, SDC1(NTF) and SDC1(CTF), have a positive effect on cell proliferation, and cell proliferation is more affected by SDC1(CTF) than by SDC1(NTF). SDC1(CTF) is involved in SUMOylation of AKT1, although the mechanism underlying SUMOylation by SDC1(CTF) remains unclear. SUMOylation of AKT1 enhances proliferation through S6 kinase signaling pathway. In C4ST-1KO cells, the cleavage of SDC1 by MMPs is suppressed because of reduced expression of MMPs. SUMOylation of AKT1 is inhibited because of decreased SDC1(CTF), and proliferation is slowed down.