Table 5.
Histologic findings of wounds on therapy against untreated and healthy skin.
| Level of Increase and wound examined | aPDT N (%) | aPDT+MU N (%) | MU N (%) | No treatment | Healthy skin | P-value |
|---|---|---|---|---|---|---|
| Conjunctive tissue | 0.951 | |||||
| -Mild -Moderate -Intense |
2 (33.3) 1 (16.7) 3 (50.0) |
2 (40) 2 (40) 1 (20) |
0 (0) 5 (83.3) 1 (16.7) |
1 (50) 0 (0) 1 (50) |
||
| Cellularity | 0.695 | |||||
| -Mild -Moderate -Intense |
1 (16.7) 2 (33.3) 3 (50) |
2 (40) 2 (40) 1 (20) |
0 (0) 5 (83.3) 1 (16.7) |
1 (50) 1 (50) 0 (0) |
||
| Rete ridge | 0.430 | |||||
| -Mild -Moderate -Intense |
2 (40) 2 (40) 1 (20) |
3 (75) 1 (25) 0 (0) |
0 (0) 4 (66.7) 2 (33.3) |
1 (50) 0 (0) 1 (50) |
||
| Follicular Cyst size | 0.033* | |||||
| -Mild -Moderate -Intense |
2 (33.3) 3 (50) 1 (16.7) |
2 (33.3) 1 (16.7) 3 (50) |
0 (0) 2 (33.3) 4 (66.7) |
1 (50) 1 (50) 0 (0) |
||
| Follicular Cyst number | 0.111 | |||||
| -Mild -Moderate -Intense |
3 (50) 2 (33.3) 1 (16.7) |
2 (33.3) 1 (16.7) 3 (50) |
1 (16.7) 2 (33.3) 3 (50.0) |
1 (50) 1 (50) 0 (0) |
||
| Epidermis Thickness (μm) (mean, SD) | 230.51 (166.38) | 209.13 (120.20) | 122.99 (78.89) | 370.82 (266.92) | 18.93 (1.04) | 0.118 |
| Dermis thickness(μm) (mean, SD) | 866.71 (217.90) | 918.09 (217.88) | 706.09 (69.01) | 1092.14 (216.53) | 346.39 (104.73) | 0.007* |
| Hyperkeratosis thickness (μm) (mean, SD) | 44.34 (36.75) | 63.71 (39.98) | 33.37 (8.52) | 152.16 | 8.76 (3.98) | 0.013* |
*
p < 0.05 significative; aPDT, antimicrobial photodynamic therapy; MU, mupirocin.