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. 2021 May 25;9:659033. doi: 10.3389/fbioe.2021.659033

TABLE 2.

Intervention strategies based on the development of advanced functional biomaterials.

(ii) Advanced functional biomaterials

Intervention strategy Examples References
Novel flexible and biocompatible polymers Extended overview Reviewed in Ordonez (2012); Ware et al. (2013), Boddupalli et al. (2016), and Fekete and Pongrácz (2017)
Polypyrrole microactuators Svennersten et al., 2011
Hydrogel core of bacterial cellulose and conductive polymer shell layer of PEDOT Chen et al., 2017
PEG-RGD hydrogels Blakney et al., 2012
SMPs Extended overview Reviewed in Ware et al. (2013)
Bioinspired cellulose nanocomposites Nguyen et al., 2014
Thiol-ene based softening substrates Arreaga-Salas et al., 2015
Micro-electro-mechanical systems (MEMS) polymer materials Polyimide Reviewed in Kozai (2018) (Lago et al., 2007; Garde et al., 2009; Mercanzini et al., 2010; Chang et al., 2013; Hassler et al., 2016; Oddo et al., 2016; Boehler et al., 2017; Delgado-Martínez et al., 2017; Wurth et al., 2017; de la Oliva et al., 2018b, c; Ji et al., 2018; Kang et al., 2019; Lee et al., 2019; Rombaut et al., 2019)
Parylene C Reviewed in Fekete and Pongrácz (2017) (Ziegler et al., 2006; Sohal et al., 2014; Xie et al., 2014; Lecomte et al., 2017; Mueller et al., 2017; de la Oliva et al., 2018a, b; Vitale et al., 2018; Kang et al., 2019)
PDMS Blau et al., 2011; Gao et al., 2013; Guo et al., 2014; Minev et al., 2015; Chatzimichail et al., 2018; Kumar et al., 2020
CP coatings Extended overview Reviewed in Aregueta-Robles et al. (2014) and Balint et al. (2014)
Hydrogels Alginate hydrogels Reviewed in Lee and Mooney (2012)
PEG-containing hydrogels Spencer et al., 2017; Zhang et al., 2017
PEG-maleimide hydrogel coatings Gutowski et al., 2015
Poly(SB) hydrogels Smith et al., 2012
PEDOT:PSS/alginate conductive hydrogels Ferlauto et al., 2018
Conducting PEDOT/PDMAAp hydrogels Kleber et al., 2017, 2019
PHEMA hydrogels Jhaveri et al., 2009; Castagnola et al., 2016; Zhang et al., 2017
Conducting hydrogels with biomolecules Reviewed in Aregueta-Robles et al. (2014) and Lotti et al. (2017) (Green et al., 2012; Mario Cheong et al., 2014; Chen et al., 2017; Staples et al., 2018)
SWNT-PPy/PEGDA composite hydrogels Xiao et al., 2012
Chemically-modified alginate microspheres Vegas et al., 2016; Bochenek et al., 2018
Zwitterionic hydrogels Phosphorylcholine polymer Yesilyurt et al., 2017
PVA/P(AM-co-SBMA) polyelectrolyte Diao et al., 2019
Poly(carboxybetaine) and pCBMA Jiang and Cao, 2010; Carr et al., 2011; Zhang et al., 2013; Trel’Ová et al., 2019
Phosphorylcholine self-assembled monolayers Chen et al., 2005
Poly(sulfobetaine) and pSBMA Reviewed in Sin et al. (2014a) (Jiang and Cao, 2010; Sin et al., 2014b; Hu et al., 2015; Wu et al., 2018)
Zwitterionic hydrogels with bioactive materials Reviewed in Von Der Mark et al. (2010)

SMPs, shape memory polymers; RGD, Arg-Gly-Asp motif; MEMs, micro-electro-mechanical systems; PDMS, poly(dimethylsiloxane); CPs, conductive polymers; PEG, polyethylene glycol; Poly(SB), polymeric sulfobetaine; PEDOT:PSS, poly(3,4-ethylenedioxythiophene):Polystyrene sulfonate; PEDOT/PDMAAp, poly(3,4-ethylenedioxythiophene)/poly(dimethylacrylamide-co-4-methacryloyloxy benzophenone-co-4-styrenesulfonate; PHEMA: poly(2-hydroxyethyl methacrylate); SWNT-PPy/PEGDA, single-walled carbon nanotubes-polypyrrole/poly(ethylene glycol) diacrylate; PVA/P(AM-co-SBMA), polyvinyl alcohol/acrylamide and sulfobetaine methacrylate copolymer; pCBMA, poly(carboxybetaine methacrylate); pSBMA, poly(sulfobetaine methacrylate). References: except were specifically indicated as ‘Reviewed in,’ all others are research articles.