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. 2021 May 25;9:659033. doi: 10.3389/fbioe.2021.659033

TABLE 3.

Intervention strategies based on the control of the interface-microenvironment interaction.

(iii) Interface-microenvironment interaction

Intervention strategy Examples References
Targeted drug delivery systems Extended overview Reviewed in Cai and Xu (2011)
Anti-inflammatory drugs Dexamethasone Reviewed in Lotti et al. (2017) and Zeglio et al. (2019) (Spataro et al., 2005; Kim and Martin, 2006; Wadhwa et al., 2006; Mercanzini et al., 2010; Luo et al., 2011; Weaver et al., 2014; Alba et al., 2015; Boehler et al., 2017; de la Oliva et al., 2018b, 2019; Kleber et al., 2019)
IL-1Ra Gutowski et al., 2015
Ibuprofen de la Oliva et al., 2018b
x Clodronate liposomes de la Oliva et al., 2018b
Diclofenac Reviewed in Zeglio et al. (2019) (Chen et al., 2017)
RGD cell adhesion ligands on glass and PEG surfaces Reviewed in Zeglio et al. (2019) (Anderson et al., 1999; Lynn et al., 2011; Blakney et al., 2012)
Functionalization of PEG surfaces with human self-peptides Reviewed in Lotti et al. (2017) (Kim et al., 2014)
Anti-fibrotic drugs Extended overview Reviewed in Lotti et al. (2017)
Targeted silencing of CTGF via siRNAs-, miRNAs- and nanoparticle-based silencing Reviewed in Leask et al. (2002); Wu et al. (2008), Miele et al. (2012); Gori et al. (2015), Salazar-Montes et al. (2015); Omar et al. (2016), Surendran et al. (2017), and Saeed et al. (2018) (Xiao et al., 2014; Yu et al., 2020)
CSF1R inhibition Doloff et al., 2017
Tissue engineering strategies for targeted drug release Extended overview Reviewed in Ratner (2002); Drury and Mooney (2003), Knop et al. (2010); Balint et al. (2014), Gori et al. (2015); Lam et al. (2015), Salazar-Montes et al. (2015), and Zeglio et al. (2019)
Human self-peptides Rodriguez et al., 2013
Conductive polymer films Wadhwa et al., 2006; Mario Cheong et al., 2014; Löffler et al., 2016
Electrically-responsive microfibers Chen et al., 2017
Milliscale dynamic soft reservoir (DSR) Dolan, 2019
Embedded microfluidic channels Metz et al., 2004; Retterer et al., 2004; Ziegler et al., 2006; Gao et al., 2013; Takehara et al., 2014; Minev et al., 2015; Elyahoodayan et al., 2020
Hydrogel coating (e.g., pHEMA, PEG-maleimide, PVA-heparin) Jhaveri et al., 2009; Mario Cheong et al., 2014; Gutowski et al., 2015
CNTs nanoreserviors Luo et al., 2011
Electronic ion pumps Isaksson et al., 2007; Simon et al., 2009; Jonsson et al., 2015; Uguz et al., 2017; Proctor et al., 2018
Microencapsulation Campioni et al., 1998
Nanoparticle-based delivery Reviewed in Wu et al. (2008); Cai and Xu (2011), Miele et al. (2012); Surendran et al. (2017), and Saeed et al. (2018) (Kim and Martin, 2006; Xiao et al., 2014; Hosseini-Nassab et al., 2017; Yu et al., 2020)
Electrically controlled drug delivery from graphene oxide nanocomposite film of PPy Weaver et al., 2014

IL-1Ra, interleukin-1 receptor antagonist; RGD, Arg-Gly-Asp motif; PEG, polyethylene glycol; CTGF, connective tissue growth factor; siRNAs, small interfering RNAs; miRNAs, microRNAs; CSF1R, colony stimulating factor-1 receptor; DSR, dynamic soft reservoir; pHEMA, poly(2-hydroxyethyl methacrylate); PVA, polyvinyl alcohol; CNTs, carbon nanotubes; PPy, polypyrrole. References: except were specifically indicated as ‘Reviewed in,’ all others are research articles.