Fig. 2.

DDT promotes proliferation of A549 epithelial cells and prevents staurosporine-induced apoptosis.

(a) A549 epithelial cells were incubated with 50 ng/ml, 100 ng/ml or 200 ng/ml of DDT for 11 d in a clonogenic assay. These increasing concentrations resulted in higher proliferation of A549 epithelial cells in a dose-dependent manner. Eight independent experiments were done. Groups were compared using a Kruskal–Wallis with Dunn's corrections test, p<0•05 was considered significant. (b) A549 epithelial cells were pre-treated with 100 ng/ml DDT or positive control CXCL12 (100 ng/ml) for 1 h prior to incubation with 100nM staurosporine (STS). Five independent experiments were done. Groups were compared using a Kruskal–Wallis with Dunn's correction for multiple testing, p<0•05 was considered significant.