Table 1.
LncRNAs that act as RNA sponges or ceRNAs to regulate EMT.
| LncRNA | Expression status in HCC | FUNCTION | Molecular mechanisms | Effect on EMT | Marker of EMT | Ref |
|---|---|---|---|---|---|---|
| DANCR | Overexpressed | RNA sponges | DANCR/miR‐27a‐3p/ LIMK1/CFL1 axis | promoted | E‐cad decreased; N‐cad and Vim increased |
2019 (37) |
| HOXA11−AS | Overexpressed | RNA sponges | HOXA11−AS/miR−506−3p/ Slug(snail 2) axis | promoted | E‐cad decreased; N‐cad and Vim increased |
2020 (38) |
| AC092171.4 | Overexpressed | RNA sponges | AC092171.4/miRNA-1271/ GRB2/ERK/AKT axis | promoted | E‐cad decreased; N‐cad and Vim increased |
2020 (39) |
| AGAP2-AS1 | Overexpressed | RNA sponges | AGAP2-AS1/miR-16-5p/ ANXA11/AKT axis | promoted | E‐cad decreased; Vim increased |
2019 (40) |
| SNHG5 | Overexpressed | RNA sponges | SNHG5/miR-26a-5p/GSK-3β axis | promoted | E‐cad and ZO-1 decreased; N‐cad and Vim increased | 2018 (41) |
| TMPO-AS1 | Overexpressed | RNA sponges | TMPO-AS1/ miR-329-3p/ FOXK1/ AKT/mTOR axis | promoted | E‐cad decreased; N‐cad increased |
2020 (42) |
| SNHG17 | Overexpressed | RNA sponges | SNHG17/miR-3180-3p/RFX1 axis | promoted | E‐cad decreased; Vim increased |
2021 (43) |
| H19 | Overexpressed | RNA sponges | H19/miRNA-22/EMT axis | promoted | N‐cad, Vim, and β-catenin increased | 2019 (44) |
| Overexpressed | RNA sponges | H19/miR-15b/CDC42/PAK1 axis | promoted | E‐cad decreased; N‐cad and Vim increased |
2019 (45) | |
| Overexpressed | RNA sponges | H19/miR-193b/MAPK1 axis | promoted | E‐cad decreased; N‐cad and β-catenin increased | 2020 (46) | |
| DLGAP1-AS1 | Overexpressed | RNA sponges | 1)DLGAP1-AS1/miR-26a/b-5p/ IL-6/JAK2/STAT3/DLGAP1-AS1 axis 2)DLGAP1-AS1/miR-26a/b-5p/ CDK8/LRP6/Wnt/β-catenin axis |
promoted | E‐cad decreased; N-cad, Vim, and twist decreased | 2020 (47) |
| LINC00355:8 | Overexpressed | ceRNA | LINC00355:8/miR-6777-3p/ Wnt10b/Wnt/β-catenin axis | promoted | E‐cad decreased; N‐cad and β-catenin increased | 2020 (48) |
| Linc-smad7 | Overexpressed | ceRNA | Linc-smad7/miR-125b/SIRT6 axis | promoted | E‐cad decreased; N‐cad and Vim increased |
2020 (49) |
| lncDQ | Overexpressed | ceRNA | LncDQ/miR-15b-5p/Wnt3A/ β-catenin/EMT axis |
promoted | E‐cad decreased; N‐cad and β-catenin increased | 2021 (50) |
| BACE1-AS | Overexpressed | ceRNA | BACE1-AS/miR-377-3p/ CELF1 axis |
promoted | E‐cad decreased; N‐cad and Vim increased |
2021 (51) |
|
lncRNA
miR503HG |
Underexpressed | ceRNA | miR503HG/miR-15b/PDCD4 axis | suppressed | E‐cad increased; N-cad, Vim, and Snail-1 decreased | 2021 (27) |
| PIK3CD−AS1 | Underexpressed | ceRNA | PIK3CD-AS1/miR-566/LAST1 axis | suppressed | E‐cad increased; Vim decreased |
2019 (52) |
| CASC2 | Underexpressed | ceRNA | CASC2/miR-367/FBXW7 axis | suppressed | E‐cad increased; Vim decreased |
2017 (53) |
| WWOX-AS1 | Underexpressed | RNA sponges | WWOX-AS1/miR-20b-5p/ WWOX axis | suppressed | E‐cad increased; N‐cad and Vim decreased | 2020 (36) |
| TUSC7 | Underexpressed | RNA sponges | TUSC7/miR-10a/EphA4 axis | suppressed | E‐cad increased; N‐cad decreased |
2016 (54) |