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. 2021 May 15;24(6):102540. doi: 10.1016/j.isci.2021.102540

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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The Chagas disease antibody response

(A and B) Mapping of individual clusters of antigens identified in this study to the gp85/trans-sialidase (A), mucin, and MASP (B) families of proteins.

(C and D) Bar graphs indicting the total number of unique peptide sequences that map to each gp85/trans-sialidase domain (C) and each multigene family (D).

(E) Alignment for gp85/trans-sialidase clusters 53, 85, and 176 with a previously described epitope (peptide G) for a neutralizing antibody; surface representation for the LamG domain of the T. cruzi Tc85-11 protein. The location of peptide G is indicated in blue.