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. 2021 Jun 3;14:3583–3596. doi: 10.2147/OTT.S302028

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© 2021 Huang et al.

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The function of ITGA2 was suppressed by AKT inhibitor MK-2206. (A)The protein level of ITGA2, AKT and p-AKT in Eca109 cells that treated with MK-2206+ITGA2, ITGA2 or Vector, respectively. CCK8 assay (B), colony formation assay (C), invasion and migration assay (D and E). For (D and E), displayed invasion and migration images were based on Transwell assays. MK-2206+ITGA2 and Vector groups were compared with the ITGA2 overexpression group, respectively. Data were statistically analyzed with paired two-tailed students, t-test. *p<0.05, **p<0.01, ***p<0.001.

Abbreviation: ns, not significant.