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. 2021 May 25;12:666296. doi: 10.3389/fphar.2021.666296

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Copyright © 2021 Jia, Gao, Huang, Guo, Zuo, Xia, Hu, Yu and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of concomitant glucocorticoids administration on the C/D ratio of VRC. The data were non-normal distribution and expressed as median with interquartile range. The ordinate (C/D ratio of VRC) was processed to the power of 0.2. DEX was abbreviation of dexamethasone, PRE was abbreviation of prednisone or prednisolone, and MET was abbreviation of methylprednisolone. N represented the number of patients enrolled and n represented the number of VRC concentrations in the group. (A) showed that the C/D ratio of VRC was significantly higher in the control patients (n = 348) than the patients receiving glucocorticoids therapy simultaneously (n = 570) (p < 0.001). (B) showed the C/D ratio of VRC in the patients accompanying different kinds of glucocorticoids compared with the control patients (n = 348). Coadministration with DEX (n = 334, p < 0.001), PRE/MET (n = 134, p = 0.005), and DEX + PRE/MET (n = 102, p < 0.001) could all reduce the C/D ratio of VRC significantly, but there was no statistical difference among these three groups (p ^b = 0.130) (Supplemental Table S1). (C) showed that the C/D ratio of VRC was significantly higher in the control patients (n = 197) than the patients receiving glucocorticoids therapy simultaneously (n = 310) (N = 60, p = 0.003). (D) showed that the C/D ratio of VRC in the patients taking DEX (n = 236) was significantly lower than the control patients (n = 197) (N = 60, p = 0.002). (E) showed that the C/D ratio of VRC in the patients taking MET (n = 31) had no statistical difference compared with the control patients (n = 51) (N = 10, p = 0.799). (F) showed that the C/D ratio of VRC in the patients taking DEX + PRE/MET (n = 35) had no statistical difference compared with the control patients (n = 37) (N = 10, p = 0.114) (Supplemental Table S2).