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The E2 CD4 T cell clone and the GSE.8E3 TCR transductant recognize different minimal epitopes. N-terminally (A) and C-terminally (B) truncated HIP11 peptides were tested with E2 and GSE.8E3 for antigenicity. Results are representative of three independent experiments. (C) Proposed binding registers for HIP11 in the context of DQ2 or DQ8 when recognized by E2 or GSE.8E3, respectively.
