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. 2021 May 25;12:628375. doi: 10.3389/fimmu.2021.628375

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Copyright © 2021 Devi-Marulkar, Moraes-Cabe, Campagne, Corre, Meghraoui-Kheddar, Bondet, Llibre, Duffy, Maillart, Papeix, Pellegrini and Michel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased carriage of HLA-DQB1genotypes encoding DQ2/DQ8 serotypes in non-responders. (A) Comparison of HLA-DRB1, DQA1, and DQB1 allele frequencies in the French Milieu Interieur (MI) cohort (n = 1,000) and in a European-American reference cohort [n = 1,899 (54)]. (B) Frequencies of DQ and DR serotype pairs in MI healthy controls, IFN non-responders and responders. (Resp = 10, NR = 9 and 8 for DR53). Pairwise comparison test between groups showed statistically significant difference of the DQ2/DQ8 frequency in NR vs MI HD (green rectangle) with *p < 0.05, adjusted for multiple comparisons. (C) Frequencies of DQ and DR serotypes in MI controls, IFN non-responders and responders.