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. 2021 May 25;12:680212. doi: 10.3389/fimmu.2021.680212

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Copyright © 2021 Lee, Rho, Roehrl and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) NFS-25 cells cultured with DS-AF568 and stained with anti-Grp78/BiP confirming the DS-accumulating compartment as the ER. (B) NFS-25 cell proteins fractionated by DS affinity and blotted with anti-Grp78/BiP. (C) NFS-25 cell proteins fractionated by DS affinity and blotted with anti-preBCR, revealing the 3 components of preBCR, each of which has different DS affinity, with IgH µ having strongest affinity. (D) NFS-25 cells cultured with DS-AF568 and stained with anti-IgH µ showing co-localization on the cell surface and in the ER. Each panel shows four quadrants: green (upper left), red (upper right), blue (lower left), and merged (lower right) channels.