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. 2021 Mar 25;16(5):1014–1020. doi: 10.1016/j.stemcr.2021.02.018

Table 1.

Examples of Names for Embryoids and Their Definitions

Name Definitions Citations
General name

Artificial embryo differentiating PSCs that model/mimic an embryo, most commonly used in the media and ISSCR Wysocka and Rossant (2019)
Embryoid first designated in 1902 to describe a tumor; more currently it refers to an organized embryoid body, made up of differentiating PSCs that model/mimic an embryo Simunovic and Brivanlou (2017)
Embryonic organoid differentiating PSCs that model/mimic an embryo Turner et al. (2017)
SHEEFs synthetic entities with embryo-like features Aach et al., (2017)
Synthetic embryo differentiating PSCs that model/mimic an embryo, most commonly used in the media Denker (2014); Warmflash (2017).

Developmental time-based name

Blastoid an embryoid modeling the blastocyst stage of development Rivron et al. (2018)
Gastruloid 2D or 3D embryoids modeling the gastrulation stage of development van den Brink et al., (2014)
PASE Post-implantation amniotic sac embryoid Shao et al. (2017)

Cell-based name

Micropatterned hESC colonies 2D models of the gastrulation stage of development Warmflash et al. (2014)
ETS embryo embryoids from embryonic and trophoblast stem cells with a 3D structure Harrison et al. (2017)
ETX embryo Embryoids from embryonic, trophoblast, and extra-embryonic endoderm stem cells Sozen et al. (2018)

h, human; ISSCR: International Society for Stem Cell Research; PSCs: pluripotent stem cells.