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. 2021 May 25;11:664421. doi: 10.3389/fonc.2021.664421

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Copyright © 2021 Zhang, Li, Lou, Chen, Yu, Kang, Chen, Zhou, Zong, Yang, Li, Xu, Jia, Geng, Chen, Dai, Tang, Yu, Wu and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Relationship between the dose and cellular kinetics. Relationships between the infusion dose and C_max (A) and AUC_{0–28 d} (B). The dose-exposure analysis showed a flat relationship between the dose and cellular kinetic parameters, with r² = 0.004 for C_max (A) and r² = 0.002 for AUC_{0–28 d} (B).