Figure 5.

Ex vivo–induced BM-MDSCs promote CD4⁺FOXP3^hCD2 cell expansion. (A) Representative flow cytometry data showing the increased frequency of CD4⁺Foxp3^hCD2 cells (Tregs) upon co-culture with ex vivo–induced BM-MDSCs with allogeneic stimulation. (B) The frequency of Tregs among whole lymphocytes increased significantly with the ex vivo–induced BM-MDSC co-culture (n = 3, ***P < 0.001, N.S. P = 0.104). (C) CD11b⁺Gr1⁺BM-MDSCs tracked using GFP mouse cells presented in corneal grafts (n = 3, ***P < 0.001).