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. 2021 May 29;24(2):544. doi: 10.3892/mmr.2021.12183

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Antinecroptosis effects of perampanel are mediated via the PTEN signaling pathway. (A) mRNA expression levels of PTEN in HT22 cells treated with hemin in the absence or presence of perampanel. (B) Representative blots and (C) quantification of protein expression levels of PTEN. (D) MTT assay of HT22 cells treated with hemin, perampanel and/or si-PTEN. (E) Representative images of live (green)/dead (red) staining assays of HT22 cells treated with hemin, perampanel and/or si-PTEN. Scale bar=100 µm. Error bars indicate SEM (n=5). ^#P<0.05 vs. vehicle group; ^&P<0.05 and ^&&P<0.01 vs. hemin group; ^£P<0.05 vs. hemin +Per group. si, small interfering; Per, perampanel; Veh, vehicle.