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. 2021 Jun 7;181(8):1055–1063. doi: 10.1001/jamainternmed.2021.2617

Table 1. Frequencies, Events, and Event Rates per 1000 Person-Years of Initial and Subsequent Clinical Fracture,a Stratified by Age and Race/Ethnicity.

Characteristic Fracture outcome
Initial fracture Subsequent fracture
No. (%) Events Rate per 1000 (95% CI) No. (%) Events Rate per 1000 (95% CI)
All participants 66 874 (100) 7142 13.9 (13.6-14.3) 7142 (100) 721 26.1 (24.3-28.1)
Age, y
<55 7713 (11.5) 574 9.0 (8.3-9.7) 574 (8.0) 33 13.2 (9.4-18.5)
55-59 13 695 (20.5) 1101 10.0 (9.4-10.6) 1101 (15.4) 63 13.8 (10.8-17.7)
60-64 16 440 (24.6) 1498 11.9 (11.3-12.6) 1498 (21.0) 115 19.5 (16.2-23.4)
65-69 14 876 (22.2) 1781 16.0 (15.3-16.8) 1781 182 26.7 (23.1-30.9)
70-74 9859 (14.7) 1403 19.6 (18.6-20.6) 1403 (19.6) 179 34.9 (30.1-40.4)
≥75 4291 (6.4) 785 26.6 (24.8-28.6) 785 (11.0) 149 54.7 (46.6-64.2)
Race/ethnicity
White 54 131 (80.9) 6392 15.4 (15.1-15.8) 6392 (89.5) 678 27.5 (25.5-29.7)
African American 7111 (10.6) 331 5.9 (5.3-6.6) 331 (4.6) 14 10.6 (6.3-17.9)
Hispanic 2900 (4.3) 191 8.8 (7.6-10.1) 191 (2.7) 14 19.0 (11.2-32.0)
Other/unknown 2732 (4.1) 228 11.1 (9.7-12.6) 228 (3.2) 15 16.2 (9.8-26.9)
American Indian/Alaska Native 370 (0.6) 29 10.6 (7.3-15.2) 29 (0.4) 2 16.7 (4.2-66.8)
Asian/Pacific Islander 1469 (2.2) 106 9.5 (7.8-11.5) 106 (1.5) 7 15.0 (7.1-31.4)
Unknown 893 (1.3) 93 14.1 (11.5-17.2) 93 (1.3) 6 17.8 (8.0-39.6)
a

Fracture sites included lower extremity (ankle, hip, patella, pelvis, shaft of femur, tibia/fibula, tibial plateau), upper extremity (carpal, elbow, lower end of humerus, radius/ulna, upper end of humerus, shaft of humerus, upper radius/ulna), and spine (lumbar spine, thoracic spine) fractures.