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. 2021 May 29;22(1):570. doi: 10.3892/ol.2021.12831

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Copyright: © Cheng et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — TNC promotes malignant progression of NPC by inducing EMT. (A) Western blot and (B) RT-qPCR analyses were performed to detect the expression levels of TNC in 5-8F and 6-10B cells following lentiviral transfection. (C) Western blot and (D) RT-qPCR analyses were performed to detect the expression levels of the EMT-related markers in stable TNC-knockdown 5-8F and 6-10B cells. Data are presented as the mean ± standard deviation (n=3). *P<0.05; **P<0.01. TNC, tenascin-C; NPC, nasopharyngeal carcinoma; EMT, epithelial-to-mesenchymal transition; RT-qPCR, reverse transcription-quantitative PCR; NC, negative control; sh, short hairpin; CDH, cadherin; VIM, vimentin; SNAIL2, snail family transcriptional repressor 2; NC, negative control.