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. 2021 Jun 8;11(33):20457–20464. doi: 10.1039/d1ra03046a

Scheme 4. Synthesis of FMK-peptides 13–16. Reagents and conditions: (i) NaOAc, EtOH, H2O, reflux; (ii) HATU, DMF, DIPEA; (iii) non-automated SPPS using Fmoc aa, HATU, DIPEA, DMF; (iv) 95% TFA, 2.5% H2O, 2.5% TIPS; (v) fully automated SPPS using Fmoc aa, HATU, DIPEA, DMF.

Scheme 4