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Clearance of circRNAs. (A) N6-methyladenosine-mediated degradation. (B) RNase L-mediated circRNA degradation after viral infection. (C) Argonaute protein 2 (AGO 2)-mediated degradation. (D) CircRNAs released in the form of extracellular vesicles. YTHDF2, YTH domain-containing family 2; HRSP12, heat-responsive protein 12; CCR4, carbon catabolite repression 4; MRP, multidrug resistance-associated protein; EMCV, encephalomyocarditis virus; RISC, RNA-induced silencing complex.
