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. 2021 Jun 15;18(2):372–387. doi: 10.20892/j.issn.2095-3941.2020.0524

Figure 5.

Figure 5

A. (a) Illustration of gold nanoprobes with acid-responsive aggregation to guide brain tumor surgery. (b) The histological H&E stained-photograph and Raman map of the glioma edge area after injection of the Au-AZ/Au-AK mixture for 24 h. (c) TEM images of GNPs in glioma and normal brain at 24 h after injection of Au-AZ/Au-AK. Red arrows indicate monodisperse GNPs, and yellow arrows indicate aggregated GNPs. Reprinted with permission from reference 99. B. Schematic diagram of PES-Au@PDA via induction of over-activation of endoplasmic reticulum (ER) stress and a pro-apoptotic UPR cascade to achieve synergistic photothermal therapy and radiotherapy for the treatment of glioblastoma. Reprinted with permission from reference 103. C. Schematic overview of the preparation of D/R@Ang2-Lip+Au and its synergistic chemotherapy, photothermal therapy, and gene therapy to treat glioblastoma. Reprinted with permission from reference 104.