Fig. 1.

Cardiometabolic trait associations with MT-CN in WGS data. A Phenome-wide association study of normalized MT-CN against 137 cardiometabolic traits in the 4163 sample data set. Traits are grouped into 17 categories, represented by the color of each bar. The top three most significant traits are, in order, fasting serum insulin, C-reactive protein, and fat mass. Exact P values and effect estimates, as calculated by EMMAX, are listed in Supplementary Table S1 (Additional File 2). B Association tests between normalized MT-CN and both fat mass and fasting serum insulin using WGS data (N = 4163). Results are shown for the EMMAX test and a permutation test in which mitochondrial haplogroups were adjusted for