Table 3.
GREML and GREML-LDMS heritability estimates for normalized MT-CN and low-density lipoprotein (LDL) in METSIM. GREML-LDMS heritability estimates are calculated using PCs 1–10 as fixed-effect covariates. Analyses of imputed array data exclude samples with WGS data.
| Trait | Genotype source (phenotype source) | Number | GREML | GREML-LDMS | ||
|---|---|---|---|---|---|---|
| h2 | SE | h2 | SE | |||
| Normalized MT-CN |
WGS (WGS-measured MT-CN) |
3065 | 0.31 | 0.07 | 0.31 | 0.09 |
| Imputed array (WES-measured MT-CN) | 6789 | 0.11 | 0.04 | 0.14 | 0.05 | |
| LDL | WGS | 3062 | 0.34 | 0.08 | 0.38 | 0.10 |
| Imputed array | 6787 | 0.25 | 0.04 | 0.32 | 0.05 | |