Table 5.

Gene-based rare variant association results for TMBIM1. TMBIM1 was the only genome-wide significant gene in the WES rare-variant association tests of METSIM and the whole dataset. Bolded results are significant at the appropriate threshold for the given test (see Methods).

	FINRISK			METSIM			Joint analysis
	Number	Fraction with rare allele	P	Number	Fraction with rare allele	P	Number	Fraction with rare allele	P
WES	9221	0.016	1.57 × 10-3	9813	0.013	1.44 × 10-6	19034	0.014	2.96 × 10-8
WGS	1084	0.028	0.489	3065	0.014	0.01	4149	0.013	0.01