Table 2.

Cox Proportional Hazard Model Including DHITsig and IPI

Variable	Overall survival		Progression-free survival
	P value	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)
IPI	0.015		0.015
Low-intermediate vs low	0.13	3.7 (0.67–20.3)	0.3554	1.8 (0.52–6.3)
Intermediate vs low	0.002	11.5 (2.40–54.8)	0.0095	4.4 (1.4–13.7)
High vs low	0.079	5.1 (0.83–30.9)	0.0049	5.0 (1.6–1.4)
DHITsig (pos vs neg)	0.041	3.0 (1.05–8.6)	0.0939	2.2 (0.87–5.3)

DHITsig, double-hit gene expression signature; IPI, International Prognostic Index; neg, negative; pos, positive.