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. 2021 May 11;16(5):1051–1064. doi: 10.1016/j.stemcr.2021.04.007

Figure 2.

Figure 2

Building better in vitro organoids using synthetic biology

(A) Cortical organoids can be generated from hiPSCs using a cocktail of small molecules and specific signaling factors.

(B) Combining normal and genetically engineered hiPSCs that turn into endothelial cells upon Dox induction can be used to make vascularized cortical organoids.

(C) Combining normal and genetically engineered hiPSCs that secrete the morphogen Shh upon Dox induction can be used to make dorsoventrally patterned brain organoids.