Figure 5.

Application of synthetic biology tools and approaches to embryo models

(A) Increasing developmental potential of embryo models: transient overexpression of Gata4 transcription factor enabled generation of a more developmentally potent mouse embryo model (Amadei et al., 2021).

(B) Potential application of synthetic rescue of a developmental mutation in embryo model.

(C) Potential description of a toy model for cavitation of an assembly of non-developmental cells CHO thanks to synthetic circuits.