Table 1.
Comparison of MDD, Vishada/Kaphaja Unmada manifestation of the patient.
| S.No | MDD | Textual Information –Vishada/Kaphaja Unmada | Patient manifestations |
|---|---|---|---|
| Aetiopathology | |||
| 1. | Genetic Factors-5-HTTLPR polymorphism | Bija dusti is the cause in many diseases. Hence it can be involved in vishada | No familial history |
| 2. | Psycho Social Factors-Job loss, marital difficulties, major health problems, and loss of close personal relationships | शोकःपुत्रादिवियोगेचित्तोद्वेगः असिद्धिभयाद्विविधेषुकर्मसुसादोऽप्रवृत्तिःविषादः (Chakrapani- C. Su 7/27) Death of son, performance or antcipatory anxiety in chronic course |
Interpersonal issues with husband, Mother in law, domestic violence, manoabhighata |
| 3. | Personality-Obsessive-Compulsive, histirionic, borderline |
Manogata-Tamasikadosha Shareerigata-vatadosha |
Tamasika Prakurti |
| 4. | Pathogenesis | ||
| 5. | Neurotransmitter- Serotonine, Ephinephrine, GABA | Tama pradhanaraja dosha |
Tama pradhanaprakurti, Kaphapittajaprakurti |
| 6. | HPA axis, Neural circuitry –Central nucleus, limbic system dysfunction | Vata (Pranavata) regulates the functioning of mind (Niyanta praneta cha manasa (C.Su.12/8)). Avalambakakapha dusti leads to hrudaya dusti | Kapha Vata |
| 7. | Psychology theory- | Tama pradhana Raja | Tama pradhana Raja |
|
Clinical manifestations Chinta, bhaya, shoka krodha lobha moha irshya have etiological role in many diseases@. Hence, these are considered as manifestations |
|||
| 8. | Neurological manifestations- Autonomic dysfunction like headache, giddiness, tinnitus. | Vatavyadhi (ch chi 28/17), Sanjaanasha, moha (C.Su.24.28) | Backache, tinnitus |
| 9. | Respiratory-Dyspnoea | Shoshana (C. Su. 25/40), | – |
| 10. | Gastrointestinal- Loss of appetite, increased appetite, weight loss, obesity |
Karshya (C.Su.21.29) Jwara (C.Ni 1/19), Ama (C .V.2/8), Trushna (C Chi 22/4) Chardi (C. Chi 20/7), Atisara (C.Chi 19/6–8), Aruchi (C.Chi 26/124) | – |
| 11. | Urogenital-Erectile dysfunction | Manasika Klaibhya (S.S.Chi 26/9) | – |
| 12. | Psychological- Anhedonia anxiety, worthlessness, helplessness, hopelessness, solitary |
Shoka, dainya, vishada, unmada, apasmara | Shoka, dainya, vishada, vishada, chinta, bhaya, krodha, dainya |
| 13. | Secondary Depression- Any chronic disorders. Irritable Bowel Syndrome, chronic fatigue syndrome (CFS), obesity, type 2 diabetes mellitus chronic pain conditions |
Any chronic condition cause vata and raja –tama increase. Vishad roga vardhanam. Shoka causes chachexia (शोकःशोषणानां. Jara) | |
| 14. | Treatment – TCA, SSRI, benzodiazepines, electroconvulsive therapy Psychotherpies- Psycosocial therapy, cognitive therapy, i nterpersonal, therapy behaviour therapy psychoanalytically-oriented, therapy, family therapy, sleep deprivation, vagal nerve stimulation, phototherapy |
Yuktivyapasharaya, satwawajaya, Daivivyapashraya, Snehapana Langhana (C.Chi. 3/139), Ashwasana (C.Chi. 3/320) (C. Chi 9/86), Harshana (C. Chi. 3/321), Saddvakhya (C. Chi 3/321) Ishtadravyaprapti (C.Chi 9/86), Santwana (C. Chi 9/86) Pratidwandwachikitsa (C. Chi 9/86) |
Yuktivyapasharaya, Satwawajaya-Mana jnana, Mana prasadan, Mana nigrahana, aswasana, Pratidwandwa chikitsa, mana vijanana. Daivivyapashraya |
@Mano dosha is a etiological factor to diseases like ama, jwara, gulma, kustha, kshaya, unmada, apasmara, pandu, atisara, chardi, trushna, vatavyadhi,vataja shiroroga.