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. 2021 Jun 7;11:107. doi: 10.1186/s13578-021-00614-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — SPD changes expression of autophagy-related genes and pathways in FGSCs. A Hierarchical clustering shows differentially expressed mRNA patterns between the control and SPD-treated groups. B Volcano plot of differentially expressed mRNAs. C Differentially expressed mRNAs are related to genes involved in the PI3K/AKT pathway. The qRT-PCR results are consistent with changes in the transcriptome profile (P < 0.05). ***P < 0.001 compared with controls. Note that one of the differentially expressed mRNAs is Bcl-2, which can inhibit cell death. D GO analysis of RNA-seq data. The top 17 significantly enriched biological processes are shown. E KEGG pathway analysis of RNA-seq data. The top seven enriched pathways are shown. Con control