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. 2021 Jun 8;13:125. doi: 10.1186/s13148-021-01111-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Epigenetic landscape in PCa. Aberrant DNA methylation (A) and histone post-translational modifications (B, C) lead to overall PCa progression and aggressiveness due to uncontrolled gene transcription signature. Black filled circles represent methylated sites (A). ac, acetylation; APC, adenomatous polyposis coli; AR, androgen receptor; CBP, CREB-binding protein; CCND2, cyclin D2; CDNK2A, cyclin-dependent kinase inhibitor 2A; CpG, cytosine/guanine enriched sites; EZH2, enhancer of zeste homolog 2; GSTP1, glutathione S-transferase Pi 1; HDAC, histone deacetylase; HOXD3, homeobox protein Hox-D3; KDM, lysine demethylase; me, methylation; MGMT, O⁶-methylguanine-DNA methyltransferase; PCa, prostate cancer; PTGS2, prostaglandin-endoperoxide synthase 2; RARβ2, retinoic acid receptor beta 2; RASSF1A, Ras association domain family member 1; SIRT, sirtuin; TGS, tumor suppressor genes