Table 1.
Experiment | Patient # included | |
---|---|---|
Figure 1 | Phenotypic screening | 10, 11, 15, 20 |
Figure 2 | T-cell proliferation and differentiation | |
(a) and (b): T-cell growth | 8, 9. 10, 11. 20, 22 | |
(c): CTV measurements | 11, 20 | |
(d) and (e): T-cell subtype | 11 | |
Figure 3 | Transduction with CAR | |
(a): CAR expression | 10 | |
(b): CAR expression | 11 | |
(c): CAR expression | 8, 9, 10, 11, 15, 20, 22 | |
(d): #CAR per cell | 10, 11, 15 | |
Figure 4 | Transduction maintained following REP | 10 |
Figure 5 | Melanoma tumor Her2 antigen expression | |
(a): S100 B expression | 10 | |
(b): S100 B expression | 11 | |
(c): melanoma tumor Her2 antigen expression | 10, 11, 34, 46 | |
(d): Melanoma sorted for High Her2 antigen expression | 11, 15 | |
(e): melanoma tumor Her2 antigen expression | 10, 11, 15, 34, 46 | |
Figure 6 | IFNγ production and cell killing | |
(a)–(f): IFNγ production | 11, 15, 20 | |
(g)–(i): cell killing | 10, 11 | |
Figure 7 | Transduction with CAR and cell phenotype | 10, 11 |
Figure 8 | TIL activity in vivo | 10 |
CAR, chimeric antigen receptor; CTV, cell trace violet; REP, rapid expansion protocol; TIL, tumor-infiltrating lymphocyte.