Table 3.
Within-subjects ADC value change after chemotherapy
| Parameters | Baseline visit | After 4-course chemotherapy | p value |
|---|---|---|---|
| ADC value (× 10–3 mm2/s) | 0.8556 (0.7130–1.361) | 1.0076 (0.8817–1.3336) | < 0.001a |
| Therapeutic response | |||
| CR | 0.8561 (0.7890–1.3884) | 1.1330 (0.9887–1.3883) | < 0.001a |
| sCR | 0.6772 (0.5985–0.9066) | 0.9756 ± 0.2724 | < 0.001a |
| PR | 0.8673 (0.7912–1.3301) | 1.0961 ± 0.2724 | < 0.001a |
| VGPR | 0.9555 ± 0.3326 | 1.0667 ± 0.2537 | 0.004a |
| SD | 1.3883 (0.8290–1.3891) | 1.2588 ± 0.2467 | 0.151 |
| PD | 0.8504 ± 0.0602 | 1.0206 ± 0.8934 | 0.089 |
| Plasma cell infiltration (%) | 44.35 ± 23.11 | 5.01 ± 7.62 | < 0.001a |
| Albumin (g/L) | 34.36 ± 7.31 | 37.44 ± 7.03 | < 0.001a |
| LDH (U/L) | 222.41 ± 85.29 | 227.94 ± 48.14 | 0.570 |
| β2 microglobulin (μg/mL) | 8.75 ± 7.15 | 4.27 ± 3.00 | < 0.001a |
ADC apparent diffusion coefficient, CR complete response, LDH lactic dehydrogenase, PD progressive disease, PR partial response, sCR strict complete response, SD sable disease, VGPR vary good partial response
aSignificant difference