Table 7.
Factors that may affect induced chemotherapy response of MM from multivariable logistic regression
| Characteristics | Treatment response | |||||
|---|---|---|---|---|---|---|
| CR | sCR | PR | VGPR | SD | PD | |
| Odds Ratio (95% confidence interval) | ||||||
| ADC value (× 10–3 mm2/s) | ||||||
| 0.3 < ADC ≤ 0.4 | 1.666 (3.439–8.069) | 2.047 (1.063–1.593) | 0.496 (0.631–2.789)* | 0.136 (0.280–1.068)* | 1.268 (0.445–1.116)* | |
| 0.4 < ADC ≤ 0.5 | 1.917 (3.912–9.396) | 0.110 (0.016–0.740)* | 0.755 (0.755–1.227)* | 1.811 (1.961–6.727) | 0.496 (0.208–2.398) | |
| 0.5 < ADC ≤ 0.6 | 3.817 (9.868–14.778) | 0.692 (0.115–4.160)* | 0.349 (0.129–0.974)* | 4.432 (0.427–1.163) | 1.219 (.0.598–1.530) | |
| 0.7 < ADC ≤ 0.8 | 5.752 (2.178–15.198) | 1.658 (0.376–7.304)* | 0.798 (0.476–1.232)* | 7.816 (0.920–1.335) | 0.553 (0.181–0.910)* | |
| 0.8 < ADC ≤ 0.9 | 1.121 (4.730–2.658)* | 5.999 (1.761–20.428) | 0.898 (1.497–10.687) | 1.632 (3.132–8.499) | 0.990 (0.202–1.392)* | |
| 0.9 < ADC ≤ 1.0 | 0.651 (0.914–1.716)* | 1.231 (0.339–4.466) | 1.452 (3.523–5.986)* | 0.608 (0.147–1.705)* | 0.802 (0.779–1.252)* | |
| 1.0 < ADC ≤ 1.1 | 3.906 (0.879–1.860) | 3.171 (0.339–4.466) | 1.501 (2.009–3.452)* | 3.917 (3.890–7.998) | 1.054 (0.371–1.529)* | |
| 1.1 < ADC ≤ 1.2 | 2.925 (1.334–6.776) | 2.496 (7.886–9.009) | 1.453 (1.650–2.221)* | 1.595 (3.435–4.667) | 0.510 (3.445–8.956)* | |
| 1.2 < ADC ≤ 1.3 | 1.334 (6.004–9.657)* | Reference | 0.399 (0.111–1.433) | 1.562 (1.312–9.673)* | 0.110 (0.005–1.127)* | 0.849 (0.445–1.956)* |
| 1.3 < ADC ≤ 1.4 | 1.679 (0.679–1.679) | 1.957 (0.598–6.410) | 1.024 (0.034–1.024) | 4.008 (0.008–0.995) | 1.389 (0.672–1.334) | |
| 1.4 < ADC ≤ 1.5 | 1.355 (0.066–1.445) | 1.769 (0.998–1.884) | 1.886 (0.554–0.981) | 0.776 (0.549–1.886)* | 0.679 (0.630–1.086) | |
| Gene variation | ||||||
| p32 deletion | 0.182 (2.397–35.169) | 0.678 (2.586–4.089)* | 3.725 (2.245–4.682) | 1.733 (1.198–4.990) | 0.645 (0.009–1.879)* | |
| P53 deletion | 0.053 (1.609–10.206)* | 0.942 (2.847–16.927) | 3.725 (0.242–1.535) | 0.359 (0.867–1.007)* | 1.828 (1.905–3.445)* | |
| RB1 deletion | 1.600 (0.856–2.991) | 2.104 (1.072–4.129) | 1.600 (0.768–3.331) | 0.290 (0.065–2.005) | 1.492 (0.067–1.992)* | |
| q21 amplification | 0.050 (1.089–3.860)* | 1.319 (0.639–2.723)** | 4.239 (2.047–8.779)* | 1.632 (0.494–5.392) | 0.985 (0.181–5.355)* | |
| IGH rearrangement | 0.640 (0.278–1.475) | 0.824 (0.332–2.045) | 0.205 (0.074–0.565) | 0.993 (0.072–2.067)* | 0.346 (0.064–1.729)* | |
ADC apparent diffusion coefficient, CR complete response, PD progressive disease, PR partial response, sCR strict complete response, SD sable disease, VGPR vary good partial response
p value for the model is less than 0.001. A single asterisk (*) implies statistically significant