Table 3.
Pertussis-antigen-specific IgG GMC in mothers at delivery and placental transfer from TdaP3-IPV- and TdaP5-IPV-vaccinated mothers to their infants
| Maternal TdaP3-IPV | Maternal TdaP5-IPV | TdaP5-IPV:TdaP3-IPV | TdaP5-IPV and TdaP3-IPV combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Antigen | N | Maternal GMC (95% CI) at delivery of infant | N | Geometric mean placental transfer ratio (95% CI) | N | Maternal GMC (95% CI) at delivery of infant | N | Geometric mean placental transfer ratio (95% CI) | Adjusteda ratio of placental transfer ratios (95% CI) | Correlation coefficientb for infant vs maternal GMC | Fold change in GMC per week, from maternal vaccination to birtha |
| PT | 51 | 37.46 (28.88–48.57) | 51 | 1.37 (1.24–1.52) | 57 | 23.77 (18.1–31.21) | 52 | 1.60 (1.47–1.73) | 1.11 (0.99–1.24) | 0.95 | 1.08 (1.05–1.10) |
| FHA | 51 | 163.96 (128.67–208.92) | 51 | 1.47 (1.34–1.62) | 57 | 68.86 (56.04–84.63) | 52 | 1.51 (1.35–1.68) | 0.95 (0.85–1.06) | 0.93 | 1.10 (1.08–1.13) |
| FIM | 51 | 22.97 (15.19–34.72) | 51 | 1.41 (1.29–1.54) | 57 | 195.71 (127.17–301.19) | 52 | 1.58 (1.43–1.74) | 1.07 (0.95–1.21) | 0.99 | 1.06 (1.04–1.09) |
| PRN | 51 | 186.06 (118.55–292.02) | 50 | 1.37 (1.21–1.55) | 57 | 181.38 (125.15–262.86) | 50 | 1.40 (1.25–1.57) | 0.95 (0.83–1.09) | 0.96 | 1.11 (1.08–1.14) |
Abbreviations: TdaP3-IPV low dose diphtheria, tetanus, acellular pertussis (three pertussis antigens), inactivated poliovirus, CI confidence interval, TdaP5-IPV low dose diphtheria, tetanus, acellular pertussis (five pertussis antigens), inactivated poliovirus, PT pertussis toxin, FHA filamentous haemagglutinin, FIM fimbriae types 2 and 3, PRN pertactin, GMC geometric mean concentration
aAdjusted for interval from maternal vaccination to birth of infant; bPearson correlation coefficient