Table 4.
Pertussis-antigen-specific IgG GMC in infants at birth, 2, 5 and 13 months of age
| Maternal TdaP3-IPV | Maternal TdaP5-IPV | Unvaccinated mothers | TdaP5-IPV:DTaP3-IPV | TdaP3-IPV:none | TdaP5-IPV:none | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Antigen | Time point | N | GMC (95% CI) | N | GMC (95% CI) | N | GMC (95% CI) | GMR (95% CI) | GMR (95% CI) | GMR (95% CI) |
| PT | Birth | 57 | 50.06 (37.55–66.75)a | 53 | 35.84 (26.73–48.05) | 0.72 (0.48–1.07) | ||||
| 2 months | 61 | 16.82 (12.64–22.37) | 70 | 10.7 (8.07–14.18) | 27 | 2.64 (1.77–3.94) | 0.64 (0.43–0.94) | 6.36 (3.82–10.61) | 4.05 (2.45–6.68) | |
| 5 months | 62 | 30.72 (26.32–35.84) | 65 | 33.55 (28.89–38.96) | 45 | 43.2 (35.5–52.58) | 1.09 (0.88–1.35) | 0.71 (0.56–0.9) | 0.78 (0.61–0.98) | |
| 13 months | 61 | 5.07 (3.95–6.51) | 63 | 6.05 (4.56–8.01) | 44 | 6.56 (4.79–9.00) | 1.19 (0.82–1.73) | 0.77 (0.51–1.16) | 0.92 (0.62–1.38) | |
| 5:2 months | 60 | 1.89 (1.33–2.69) | 65 | 3.25 (2.29–4.62) | 27 | 14.1 (8.67–22.93) | 1.72 (1.05–2.81) | 0.13 (0.07–0.25) | 0.23 (0.12–0.43) | |
| FHA | Birth | 57 | 245.79 (190.72–316.76) | 53 | 97.44 (78.44–121.03) | 0.4 (0.29–0.55) | ||||
| 2 months | 61 | 66.37 (51.95–84.79) | 70 | 31.74 (26.05–38.68) | 27 | 5.97 (4.02–8.87) | 0.48 (0.35–0.65) | 11.12 (7.36–16.79) | 5.32 (3.55–7.96) | |
| 5 months | 62 | 54.52 (47.75–62.25) | 65 | 50.67 (43.92–58.45) | 45 | 67.31 (55.02–82.34) | 0.93 (0.77–1.13) | 0.81 (0.65–1.01) | 0.75 (0.6–0.94) | |
| 13 months | 61 | 14.01 (11.25–17.43) | 63 | 18.07 (13.81–23.64) | 44 | 22.2 (17.15–28.72) | 1.29 (0.92–1.81) | 0.63 (0.44–0.91) | 0.81 (0.57–1.17) | |
| 5:2 months | 60 | 0.83 (0.65–1.05) | 65 | 1.67 (1.3–2.15) | 27 | 10.37 (6.31–17.04) | 2.02 (1.43–2.84) | 0.08 (0.05–0.13) | 0.16 (0.1–0.26) | |
| PRN | Birth | 56 | 250.13 (160.52–389.77) | 52 | 230.53 (151.1–351.7) | 0.92 (0.51–1.68) | ||||
| 2 months | 62 | 62.51 (39.17–99.75) | 70 | 83.02 (59.29–116.25) | 27 | 2.63 (1.44–4.82) | 1.33 (0.76–2.32) | 23.73 (11.46–49.15) | 31.52 (15.41–64.46) | |
| 5 months | 62 | 65.88 (55.66–77.96) | 65 | 53.32 (42.59–66.76) | 44 | 73.85 (54.41–100.22) | 0.81 (0.61–1.08) | 0.89 (0.64–1.24) | 0.72 (0.52–1) | |
| 13 months | 60 | 10.47 (8.18–13.42) | 63 | 7.04 (5.33–9.30) | 40 | 11.24 (8.4–15.04) | 0.67 (0.47–0.97) | 0.93 (0.62–1.39) | 0.63 (0.42–0.93) | |
| 5:2 months | 61 | 1.06 (0.64–1.75) | 65 | 0.65 (0.45–0.93) | 27 | 26.54 (11.81–59.62) | 0.62 (0.34–1.12) | 0.04 (0.02–0.09) | 0.02 (0.01–0.05) | |
| FIM | Birth | 56 | 34.09 (22.77 –51.04) | 53 | 282.36 (177.32–449.62) | 8.28 (4.55–15.09) | ||||
| 2 months | 61 | 9.82 (6.71–14.37) | 70 | 85.5 (59.59–122.67) | 27 | 5.2 (2.94––9.21) | 8.71 (5.2 –14.58) | 1.89 (0.96–3.71) | 16.43 (8.47–31.88) | |
| 5 months | 62 | 3.64 (2.77–4.79) | 65 | 18.47 (13.58–25.12) | 45 | 2.32 (1.73–3.12) | 5.07 (3.38–7.61) | 1.57 (1.02–2.41) | 7.95 (5.19–12.16) | |
| 13 months | 61 | 1.54 (1.26–1.87) | 63 | 1.49 (1.24–1.79) | 44 | 1.21 (0.92–1.60) | 0.97 (0.75–1.26) | 1.27 (0.93–1.72) | 1.23 (0.91–1.67) | |
| 5:2 months | 60 | 0.38 (0.3–0.48) | 65 | 0.22 (0.19–0.26) | 27 | 0.49 (0.33–0.71) | 0.58 (0.44–0.76) | 0.79 (0.55–1.14) | 0.46 (0.32–0.66) | |
Abbreviations: DdaP3-IPV low dose diphtheria, tetanus, acellular pertussis (three pertussis antigens), inactivated poliovirus, TdaP5-IPV low dose diphtheria, tetanus, acellular pertussis (five pertussis antigens), inactivated poliovirus, GMC geometric mean concentration, CI confidence interval, GMR geometric mean ratio, PT pertussis toxin, FHA filamentous haemagglutinin, FIM fimbriae types 2 and 3, PRN pertactin
aThe GMC of anti-PT IgG was lower than the limit of detection for one infant at birth
Blood samples were not collected at birth from infants born to women not receiving a pertussis-containing vaccine in pregnancy as these women and infants were only recruited in the postnatal period; therefore, corresponding cells are empty