Table 3.
Adjusted associations between nanoplaque levels and IL-8 and MIP-1α
| Model 1 | Model 2 | |||
|---|---|---|---|---|
| β-coefficient (CI) | P | β-coefficient (CI) | P | |
| Dependent variable: IL-8 pg/ml | ||||
| CSF nanoplaquesa | −3.830 (−6.038; −1.622) | 0.001 | −3.536 (−5.821; −1.250) | 0.003 |
| Male sex | −0.802 (−3.376; 1.773) | 0.538 | − 1.071 (− 3.682; 1.540) | 0.418 |
| Age | −0.054 (− 0.214; 0.106) | 0.505 | − 0.029 (− 0.203; 0.144) | 0.737 |
| CDR-SOB | 0.170 (− 0.390; 0.731) | 0.548 | 0.144 (− 0.431; 0.720) | 0.620 |
| APOE ε4 | −0.452 (− 1.818; 0.915) | 0.513 | − 0.373 (− 1.799; 1.054) | 0.605 |
| CSF Aβ42 pg/ml | 0.002 (−0.002; 0.007) | 0.321 | ||
| CSF P-tau pg/ml | 0.018 (−0.015; 0.052) | 0.285 | ||
| Dependent variable: MIP-1α pg/ml | ||||
| CSF nanoplaquesa | −0.083 (− 0.133; − 0.034) | 0.001 | −0.079 (− 0.127; − 0.031) | 0.002 |
| Male sex | 0.049 (− 0.010; 0.107) | 0.101 | 0.037 (− 0.018; 0.092) | 0.180 |
| Age | 0.005 (0.002; 0.009) | 0.006 | 0.005 (0.001; 0.009) | 0.009 |
| CDR-SOB | 0.012 (−0.001; 0.025) | 0.064 | 0.007 (−0.005; 0.019) | 0.233 |
| APOE ε4 | 0.030 (−0.001; 0.061) | 0.058 | 0.023 (−0.007; 0.053) | 0.128 |
| CSF Aβ42 pg/ml | 0.000 (−0.000; 0.000) | 0.486 | ||
| CSF P-tau pg/ml | 0.001 (0.001; 0.002) | < 0.001 | ||
Aβ amyloid-β, APOE apolipoprotein E, CI confidence interval, CDR-SOB Clinical Dementia Rating Scale Sum of Boxes, CSF cerebrospinal fluid, fseo frequency of single event occurrence per hour, IL-8 interleukin-8, MIP-1α macrophage inflammatory protein 1α, P-tau phosphorylated tau
aLog (fseo). The β-coefficient denotes the degree of change in the dependent variable (IL-8 or MIP-1α) for a one-step change in the continuous predictor variables or the presence of the dichotomised predictor variables