Table 1.

Endpoint definitions: brachial plexus toxicity grading scales

	CTCAE Version 3.0 [21]	CTCAE Version 4.0 [22]	Modified LENT-SOMA scale [23]
Grade 1	Asymptomatic brachial plexopathy	Asymptomatic effects	Mild sensory deficits, no pain, no treatment required
Grade 2	Symptomatic brachial plexopathy without interfering with activities of daily living (ADL)	Moderate symptoms limiting ADL	Moderate sensory deficits, tolerable pain, mild arm weakness
Grade 3	Symptomatic brachial plexopathy and interfering with ADL	Severe symptoms limiting self care ADL	Continuous paresthesia, with incomplete paresis, pain medication required
Grade 4	Disabling brachial plexopathy	N/A	Complete paresis, excruciating pain, muscle atrophy, regular pain medication required

CTCAE common terminology criteria for adverse events, LENT late effects normal tissues, SOMA subjective, objective, management, analytic, ADL activities of daily living