Table 3.
Published dose constraints that are plotted in the DVH Risk Map in Fig. 2 of the paper
| # Fractions | Volume cc | Volume % | cc or % limit Gy | Max limit Gy | Mean limit Gy | Approx # AE ≥ G3 | Approx # Pts dose | # Pts in study | Refs | Notes |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 5 | 14.4 | 0 | 33 | [43, 44] | RTOG 0631, limit is for sacral plexus | ||||
| 1 | 0.03 | 18 | 0 | 33 | [43, 44] | RTOG 0631, limit is for sacral plexus | ||||
| 1 | 3 | 14 | [43, 44] | RTOG 0631 | ||||||
| 1 | 3 | 14 | 1 | 33 | [44] | One G3 possible radiosurgery-related AE (neck pain) | ||||
| 1 | 0.03 | 17.5 | [43, 44] | RTOG 0631 | ||||||
| 1 | 0.03 | 17.5 | 1 | 33 | [44] | One G3 possible radiosurgery-related AE (neck pain) | ||||
| 1 | 17.5 | [45, 46] | RTOG 0915, TG101 | |||||||
| 1 | 16 | [47] | Also for sacral plexus | |||||||
| 1 | 3 | 14.4 | [47] | Also for sacral plexus | ||||||
| 1 | 3 | 14 | [45, 46] | RTOG 0915, TG101 | ||||||
| 1 | 10 | 0 | 23 | [48, 49] | ||||||
| 1 | 8 | 0 | 32 | [50] | ||||||
| 3 | 56.7 | [51] | RTOG 1021 acceptable deviation | |||||||
| 3 | 27 | [52] | ||||||||
| 3 | 26 | 7 | 37 | [1, 53] | 100 Gy BED3, 14% risk, 46% above, 8% below | |||||
| 3 | 24 | [46, 47, 51, 54–65] | RTOG 0618, 1021, Accuray STARS, Also for sacral plexus, TG101 | |||||||
| 3 | 24 | 0 | 10 | [56] | ||||||
| 3 | 24 | 0 | 38 | [52, 62] | ||||||
| 3 | 24 | 0 | 79 | [63] | ||||||
| 3 | 24 | 0 | 70 | [65] | ||||||
| 3 | 3 | 22.5 | [47] | Also for sacral plexus | ||||||
| 3 | 3 | 20.4 | [46, 51] | TG101, RTOG 1021 | ||||||
| 4 | 42.5 | 1 | 1 | 27 | [66] | 20% of brachial plexus > 40gy in one pt who had G3 AE | ||||
| 4 | 20% | 40 | 1 | 1 | 27 | [66] | 20% of brachial plexus > 40gy in one pt who had G3 AE | |||
| 4 | 40 | 1 | 27 | [53, 59, 66, 67] | Accuray STARS, 1 AE at 40 Gy described in Chang 2015 | |||||
| 4 | 1 | 35 | 27 | [59, 66] | Accuray STARS | |||||
| 4 | 10 | 30 | 27 | [59, 66] | Accuray STARS | |||||
| 4 | 26 | [1, 53] | This limit has been attributed to 3–4 fractions | |||||||
| 4 | 35 | 3 | 9 | 82 | [68] | |||||
| 4 | 0.2 | 30 | 3 | 7 | 82 | [68] | ||||
| 4 | 32 | [52] | ||||||||
| 4 | 27.2 | [45, 69] | RTOG 0915 | |||||||
| 4 | 3 | 23.6 | [45] | RTOG 0915 | ||||||
| 5 | 45 | 1 | 12 | [63] | ||||||
| 5 | 35 | [52] | ||||||||
| 5 | 1 | 40 | 50 | [70] | ||||||
| 5 | 32 | [47, 71] | RTOG 0813, QOD, Also for sacral plexus | |||||||
| 5 | 30.5 | [46] | TG101 | |||||||
| 5 | 30 | [72] | ||||||||
| 5 | 29.6 | [69] | ||||||||
| 5 | 3 | 30 | [47, 71] | RTOG 0813, QOD, Also for sacral plexus | ||||||
| 5 | 3 | 27 | [46] | TG101 | ||||||
| 7 | 35 | [72] | ||||||||
| 8 | 37 | 0 | 46 | [73] |
cc cubic centimeters, Approx approximate, AE adverse event (brachial plexopathy), G3 grade 3 or higher, Pts patients, Rx received, Refs references, RTOG radiation therapy oncology group, TG task group, QOD every other day, BED biological effective dose