Table 3.
15 Kinds of serum bile acids in different groups
| Normal pregnant woman group (n = 50) | ICP1 (n = 51) | ICP2 (n = 27) | ICP3 (n = 22) | ICP4 (n = 44) | Cholelithiasis (n = 50) | hepatitis B virus (n = 50) | H value | P value | |
|---|---|---|---|---|---|---|---|---|---|
| LCA | 6.78 (5.15, 12.87) | 3.81 (0.37, 12.22)a | 9.73 (1.59, 16.04) | 27.97 (6.19, 65.14)a,b,c,d | 7.60 (1.74, 16.78) | 7.46 (4.61, 18.13)b | 3.38 (0.00, 11.91) | 26.389 | 0.000 |
| UDCA | 26.56 (12.91, 63.12) | 16.40 (5.99, 2156.61) | 299.49 (16.25, 959.76)a | 791.55 (343.89, 1685.69)a,c,d | 211.79 (41.88, 611.20)a,c,d | 57.35 (10.75, 145.08) | 39.90 (8.51, 137.31) | 39.197 | 0.000 |
| CDCA | 63.78 (22.29, 127.39) | 14.37 (7.58, 55.29)a | 36.55 (11.71, 85.63) | 83.95 (37.14, 344.09)b,c,d | 41.46 (11.29, 79.14)c,d | 201.44 (70.61, 691.10)a,b | 269.75 (83.64, 682.13)a,b | 91.967 | 0.000 |
| DCA | 134.22 (61.01, 189.83) | 23.89 (4.20, 86.86)a | 69.51 (12.71, 148.48) | 354.69 (96.47, 699.47)b,d | 154.29 (71.14, 283.26)b,d | 57.75 (6.05, 375.86) | 6.00 (2.04, 161.40)a | 40.844 | 0.000 |
| CA | 55.06 (30.96, 133.01) | 140.71 (38.58, 543.40) | 67.84 (29.19, 119.43) | 146.77 (60.03, 648.8) | 56.55 (25.88, 196.19)d | 101.27 (35.50, 304.24) | 470.85 (114.04, 1689.49)a,b | 61.819 | 0.000 |
| GLCA | 3.39 (0.00, 6.67) | 4.46 (2.27, 15.82)a | 5.75 (2.92, 27.64)a | 28.88 (7.07, 65.77)a,b,c | 6.28 (3.24, 13.80)a,d | 5.27 (3.91, 15.48)a | 19.81 (5.78, 39.46)a,b | 24.321 | 0.000 |
| GUDCA | 141.22 (77.47, 223.13) | 2453.22 (632.41, 4416.73)a | 2753.28 (1263.88, 5018.57)a | 2092.63 (1277.99, 3306.3)a,c,d | 824.15 (364.58, 1524.56)a,b,c | 115.62 (64.37, 341.49)b | 659.29 (314.72, 2030.89)a,b | 150.749 | 0.000 |
| GCDCA | 689.64 (405.26, 1155.35) | 2587.20 (1447.06, 4949.62)a | 2716.70 (1616.13, 4433.8)a | 3834.13 (2001.43, 6069.68)a,c,d | 722.24 (385.83, 994.84)b,c,d | 1734.37 (958.24, 4784.75)a | 18, 254.50 (6526.70, 60, 229.00)a,b | 159.991 | 0.000 |
| GDCA | 259.82 (125.04, 431.66) | 185.93 (62.06, 504.23) | 416.33 (123.87, 1123.29) | 861.1 (497.66, 2153.76)a,b,c,d | 222.82 (93.66, 427.65) | 137.46 (43.21, 333.13) | 270.39 (22.89, 824.99) | 39.306 | 0.000 |
| GCA | 245.02 (160.14, 405.87) | 5107.28 (2337.71, 10, 380.40)a | 2297.14 (1520.24, 6281.02)a | 4235.73 (2052.99, 9929.26)a,c,d | 647.49 (539.83, 934.85)a,b,c | 243.94 (97.07, 1302.62)b | 15, 199.35 (3820.78, 62, 330.67)a,b | 54.292 | 0.000 |
| TLCA | 3.25 (0.00, 6.09) | 5.58 (4.05, 14.36)a | 7.23 (3.42, 17.50)a | 14.72 (4.06, 28.76)a,c,d | 2.88 (1.65, 4.03)b,c | 4.33 (2.84, 6.67) | 4.26 (0.32, 12.07) | 128.749 | 0.000 |
| TUDCA | 9.09 (3.72, 16.92) | 565.99 (27.01, 1972.32)a | 581.77 (53.22, 984.79)a | 441.97 (144.24, 1222.01)a,c,d | 96.89 (37.62, 164.88)a,c | 5.25 (3.34, 14.94)b | 63.8 (13.07, 149.13)a,b | 141.125 | 0.000 |
| TDCA | 111.11 (54.11, 187.14) | 182.08 (81.71, 443.78) | 248.21 (73.67, 585.44) | 375.06 (72.56, 507.48)a,c,d | 59.24 (27.70, 124.67)b,c | 20.98 (5.00, 80.12)a,b | 72.91 (10.09, 188.84)b | 47.217 | 0.000 |
| TCDCA | 313.07 (148.56, 547.40) | 2546.27 (1213.19, 6120.77)a | 1333.51 (845.08, 3308.70)a | 1082.66 (470.28, 1458.14)a,b,c,d | 168.34 (110.16, 402.18)b,d | 156.72 (83.72, 1183.87)b | 5285.51 (1169.15, 16, 671.87)a | 123.417 | 0.000 |
| TCA | 143.90 (91.89, 319.64) | 8656.79 (2542.60, 20, 058.10)a | 2210.20 (866.51, 5769.00)a,b | 1425.13 (830.08, 4644.10)a,b,c | 209.71 (129.25, 434.93)b,c,d | 42.78 (18.52, 360.43)a,b | 3294.19 (667.89, 13, 783.69)a | 116.092 | 0.000 |
The data in the table is expressed by Median (Q1, Q3). Data unit is nmol/L. Pairwise comparisons between groups were performed using Bonferroni correction
aCompared with the normal pregnant women group, P < 0.008
bCompared with the ICP1 group, P < 0.01
cCompared with gallstone group P < 0.025
dCompared with the hepatitis B virus group, P < 0.025