Table 8.
Clinical information and liver function test results of normal pregnant women and patients in every subgroup of ICP
| Subjects | Normal pregnant (n = 50) | ICP1 (n = 51) | ICP2 (n = 27) | ICP3 (n = 22) | ICP4 (n = 44) | H/χ2 | P |
|---|---|---|---|---|---|---|---|
| Age (year) | 28 (26, 32) | 30 (27, 31) | 29 (23, 33) | 28 (27, 31) | 29 (27, 33) | 1.441 | 0.837 |
| Gravidity | 2 (1, 3) | 2 (1, 3) | 2 (1, 3) | 1 (1, 2) | 2 (1, 2) | 8.069 | 0.089 |
| Delivery pregnancy week | 39 (38, 40) | 37 (35, 39)a | 37 (36, 38)a | 38 (37, 39.0)a | 37 (36, 39)a | 36.587 | 0.000 |
| Previous history of ICP (n, %) | 0 (0%) | 2 (3.9%) | 5 (18.5%)a | 2 (9.1%) | 4 (9.1%) | 10.855 | 0.028 |
| Pregnancy outcome (n, %) | |||||||
| Cesarean section | 4 (8%) | 42 (82.4%)a | 18 (66.7%)a,b | 8 (36.7%)b | 18 (40.9%)a,b | 53.982 | 0.000 |
| Premature (< 37w) | 0 (0%) | 39 (76.5%)a | 2 (7.4%)a,b | 2 (9.1%)a,b | 5 (11.4%)a,b | 30.81 | 0.000 |
| Meconium-stained amniotic fluid | 1 (2%) | 19 (37.3%)a | 4 (14.8%)a,b | 3 (13.6%)a,b | 8 (18.2%)a,b | 27.324 | 0.000 |
| Neonatal ICU hospitalization rate | 1 (2%) | 17 (33.3%)a | 5 (18.5%)a | 0 (0%) | 5 (11.4%) | 25.422 | 0.000 |
| 1 min Apgar scores ≤ 7 | 1 (2%) | 12 (23.5%)a | 2 (7.4%) | 2 (9.1%) | 3 (6.8%)b | 21.185 | 0.000 |
| Newborn weight (g) | 3305 (2980, 3592) | 3180 (2720, 3370)a | 2900 (2720, 3360)a | 3185 (2837, 3320) | 2960 (2565, 3870) | 10.774 | 0.029 |
| Postpartum hemorrhage (ml) | 225 (200, 300) | 200 (200, 300) | 300 (200, 300) | 200 (200, 285) | 300 (200, 300)a | 11.077 | 0.026 |
| Liver function test results | |||||||
| TBA (umol/L) | 3.3 (2.4, 4.5) | 32.0 (16.5, 48.1)a | 18.8 (12.0, 28.8)a,b | 19.9 (16.9, 29.4)a | 6.2 (4.4, 7.4)a,b,c | 149.387 | 0.000 |
| TBIL (umol/L) | 11.0 (8.8, 12.9) | 18.0 (13.4, 26.6)a | 8.4 (5.4, 12.1)a,b | 6.5 (4.5, 10.1)a,b | 8.2 (6.3, 10.4)a,b | 94.044 | 0.000 |
| DBIL (umol/L) | 3.4 (2.6, 4.8) | 12.6 (8.3, 16.8)a | 3.7 (2.2, 5.1)a,b | 3 (2.4, 3.6)a,b | 3.8 (3.0, 4.5)a,b,d | 123.664 | 0.000 |
| ALT (U/L) | 19.0 (17.0, 25.3) | 216.0 (106.0, 336.0)a | 176.0 (95.0, 309.0)a | 10.0 (7.8, 13.5)a,b | 104.5 (70.0, 174.8)a,b,d | 142.102 | 0.000 |
| AST (U/L) | 18.0 (15.8, 22.0) | 146.0 (73.0, 205.0)a | 116.8 (60.0, 232.0)a | 15.5 (12.0, 18.0)a,b | 51.5 (35.3, 76.5)a,b,d | 141.737 | 0.000 |
The data in the table is expressed by M (Q1, Q3)
aP < 0.05 compared with normal pregnant women
bCompared with ICP1 group, P < 0.05
cCompared with the ICP2 group, P < 0.05
dComparing the ICP3 group with the ICP4 group, P < 0.05