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. 2021 Jun 8;19:171. doi: 10.1186/s12951-021-00918-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — A The highest temperature of nude mice xenografts in different groups after 10 min of NIR light irradiation. B Tail vein injection group. "+" is the highest temperature area which measured by NIR imager. (a) Tumor before treatment, (b) Tumor after 5 treatments, (c) The maximum temperature is 33.8 °C (non-tumor tissue temperature) before treatment, (d) The maximum temperature after 10 min of treatment (tumor tissue temperature) reached 43.7 °C. C Control group. "+" is the highest temperature area which measured by NIR imager. (a) Tumor before treatment, (b) Tumor after treatment 5 times, (c) The highest temperature before treatment is 34.0 °C (non-tumor tissue temperature), (d) The highest temperature after treatment reaches 41.8 °C 10 min (tumor tissue temperature). D and E Changes in tumor volume pre- and post-treatment in the tail vein injection group, control group, nanoparticles without laser irradiation group and blank group. F Changes of weight in nude mice pre- and post-treatment among the tail vein injection group, control group, nanoparticles without laser irradiation group and blank group. G HE staining. More apoptotic cells were seen in the tail vein injection group (a), but very few in the control group (b), the blank group (c) and the nanoparticles without laser irradiation group (d)