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. 2021 Jun 7;18:58. doi: 10.1186/s12986-021-00582-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The c-Fos expression in the brain after refeeding and distribution of GLP-1R in the DMH. A–F: The representative images of c-Fos expression in the SCN (A, D), DMH (B, E) and NTS (C, F) after fasting (A–C) or refeeding (D–F) rats. Refeeding was performed for 2 h after 16 h of fasting in normal 12 h light/12 h dark conditions. Scale bar = 100 μm. G: The number of c-Fos per sections in feeding-related brain regions. (n = 4 each). ARC: arcuate nucleus, Amy: amygdala, BNST: bed nucleus of stria terminalis, DMH: dorsomedial hypothalamic nucleus, DR: dorsal raphe, LC: locus coeruleus, NTS: nucleus tractus solitarius, SCN: suprachiasmatic nucleus, SON: supraoptic nucleus, SuM: supramammillary nucleus, POA: preoptic area, PVN: paraventricular hypothalamic nucleus, VMH: ventromedial hypothalamic nucleus. H–J DAPI nuclear staining (H) and GLP-1R immunostaining (I) in the DMH and a merged image of H and I (J). Scale bars = 100 μm. Each image located in the upper left corner of H–J is an enlarged image of the dashed square. Scale bars = 10 μm