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. 2021 Jun 7;18:58. doi: 10.1186/s12986-021-00582-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SCN projecting DMH neurons with GLP-1R expression increase c-Fos after feeding. A The injection site of the retrograde tracer, CTB in the SCN. Scale bar = 100 μm. B The distribution of CTB-positive neurons in the DMH. C The distribution of GLP-1R-positive neurons in the DMH. D A merged image of B and C. Scale bars = 50 μm. The enlarged images located in the left corner in the image of B–D indicate the image in the dotted white square in the respective image. Scale bars = 10 μm. Arrowheads indicate the neurons co-localizing CTB and GLP-1R. E–J: The distribution of CTB-positive neurons (E, H), c-Fos-positive neurons (F, I) and a merged image (G, J) in the DMH of a control fasting (E–G) or refeeding (H–J) rat. Scale bars in E–J indicate 10 μm. K The percentage of c-Fos-positive neurons among CTB-positive neurons in the DMH. (n = 5, 4) ** P < 0.01, Student t-test