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Enhanced CLEC12A-ENG.CD123IL7Rα T-cell activation is secondary to CD123+ target recognition and intact IL7Rα elements. IFNγ (A) and IL2 (B) secreted into supernatant following the culture of indicated effector and target cells, (n = 4 T-cell donors, *, P< 0.05; **, P< 0.01). C, Relative change in IFNγ secretion in T cells cultured with K562.CLEC12A versus K562.CLEC12A.CD123 (n = 1 T-cell donor).
