Table 2.
Antigens which are the targets of significantly higher IgG responses in DIV, compared to CI, subjects 18 months after PZQ treatment.
| Antigen (WBPS141 Accession) | Description | CI cohort SI2 | DIV cohort SI3 | Fold change4 | P value5 | Selection method for array inclusion6 |
|---|---|---|---|---|---|---|
| MS3_01693 | cystatin | 36.769 | 1365.483 | 37.137 | 0.030 | bioinformatic |
| MS3_02176 | microsomal glutathione S-transferase 3 | 495.452 | 1362.997 | 2.751 | 0.027 | proteomic (T) |
| MS3_01105 | universal stress protein | 35.769 | 1214.122 | 33.943 | 0.030 | proteomic (AES) |
| MS3_06126 | sulfide quinone reductase, putative | 114.734 | 1035.405 | 9.024 | 0.002 | bioinformatic |
| MS3_07195 | ribosomal protein S11 | 118.385 | 1000.316 | 8.450 | 0.026 | bioinformatic |
| MS3_07763 | succinyl-CoA ligase subunit beta, mitochondrial | 107.417 | 958.094 | 8.919 | 0.045 | proteomic (SEA) |
| MS3_05425 | 14 kDa subunit splicing factor 3b | 123.558 | 934.925 | 7.567 | 0.050 | proteomic (AES) |
| MS3_08689 | synaptic vesicle membrane protein VAT-1-like protein | 206.939 | 918.716 | 4.440 | 0.046 | bioinformatic |
| MS3_06283 | dexamethasone-induced Ras-related protein 1 | 156.625 | 875.308 | 5.589 | 0.024 | bioinformatic |
| MS3_04279 | saposin B domain-containing protein | 68.077 | 822.758 | 12.086 | 0.047 | bioinformatic/EV homologue |
| MS3_01972 | leptin receptor overlapping transcript-like 1 | 77.240 | 768.733 | 9.952 | 0.004 | proteomic (SEA) |
| MS3_00257 | regulator of microtubule dynamics protein 1 | 77.878 | 697.027 | 8.950 | 0.045 | bioinformatic |
1WormBase ParaSite online database, version 14 https://parasite.wormbase.org/Schistosoma_haematobium_prjna78265/Info/Index/.
2mean signal intensity of CI cohort 18 month after PZQ treatment.
3mean signal intensity of DIV cohort 18 months after PZQ treatment.
4fold change in mean signal intensity of CI cohort compared to DIV cohort 18 months after PZQ treatment.
5significance of difference in mean signal intensity of CI cohort compared to DIV cohort 18 months after PZQ treatment.
6proteins for array inclusion selected from bioinformatic analysis of second-generation S. mansoni array (16) or analysis of S. haematobium proteomes (13, 14).
T, S. haematobium adult tegument, AES, S. haematobium adult excretory/secretory products, SEA, S. haematobium soluble egg antigen.